A GC method with headspace injection for determination of residual organic solvents acetone andn-hexane in andrographolide microcapsules was established. A CP-624 column was used with FID detection. The calibrationcurves of acetone and n-hexane were linear in the ranges of 100～900mg (r=0.9999) and 5.8～52.2mg(r=0.9963),respectively. The average recoveries were 101.2% (RSD=1.78%) and 100.9% (RSD=2.51%), respectively. Thedetection limits were 64 and 18ng, respectively.
