提出绝经后女性骨小梁的体密度(volume bone mineral density,vBMD)、力学特性与组织形态计量参数在体分析方法,揭示其在不同解剖学区域的特异性分布规律,骨小梁组织结构与力学特点的局部相关关系。运用高分辨率外周定量断层扫描(high resolution peripheral quantitative computed tomographic,HR-pQCT),首次建立了骨密度区域映射方法和骨小梁与骨髓多材料有限元模型,在体分析了10名绝经后女性骨小梁在胫骨前、后、外、内侧4个解剖区域的骨密度分布与力学特点区域间特异性。运用统计学方法分析组织形态参数与刚度局部区域间的相关性。研究发现骨小梁力学特性、结构与密度在不同解剖学部位的差异具有显著性差异,最低(前侧)骨小梁的强度为最高(内侧)区域的29.11%(P<0.05)。并且发现胫骨前侧和后侧、内侧和外侧都表现出了显著的两两相关的关系。骨小梁与骨髓多材料有限元模型方法为在体分析骨小梁力学与材料特性提供了可能方法。骨组织结构存在区域间相关关系,对了解胫骨材料特点,预测胫骨骨折部位具有指导性意义。
Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes.High resolution peripheral quantitative computed tomography(HR-pQCT)enables in vivo microstructure characterization but is limited in its ability to visualize important biological features.We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease(CVD)and type 2 diabetes mellitus(T2D).Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility.These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.
Barbara GaritaJenna MaligroSaghi SadoughiPo Hung WuEllen LiebenbergAndrew HorvaiThomas M.LinkGalateia J.Kazakia
Objective: To use peripheral quantitative computed tomography (pQCT) to determine bone measurements in patients with cerebral palsy (CP) age 3 to 20 years and compare them with control subjects. Study design: A total of 13 (5 male) patients with CP, along with 2 sex-and age-matched controls for each, were included in a mixed-model analysis with matched pairs as random effects for pQCT bone measurements of the 20%distal tibia. Results: Tibia length was similar in the CP and control groups (P = .57). Weight was marginally higher in the control group (P = .06). Cortical bone mineral content (BMC), area, thickness, polar strength-strain index (pSSI), and periosteal and endosteal circumferences were greater in the control group (P < .05 for all). Relationships between bone measurements and weight showed that cortical BMC, area, periosteal circumference, and pSSI were greater at higher weights in the control group (group-by-weight interaction, P < .05 for all). Cortical thickness was greater in the control group and was correlated with weight. Cortical volumetric bone mineral density (vBMD) was greater with higher weights in the CP group (group-by-weight interaction, P = .03). Conclusions: Bone strength, as indicated by pSSI, is compromised in children with CP due to smaller and thinner bones, not due to lower cortical bone density.
