本文深入探讨了儿童癫痫停药复发的相关研究现状。文章首先概述了癫痫在儿童中的发病率以及抗发作药物(ASMs)治疗的普遍性和局限性。重点分析了停药策略,包括无发作时间的确定、药物减量过程,以及单一药物与多药联合治疗的考量。进一步讨论了停药后复发的多种危险因素,如人口统计学因素、癫痫发作的严重程度、癫痫综合征、发作类型、病因、脑电图(EEG)异常、热性惊厥史和家族史,以及其他相关疾病或并发症。此外,综述了儿童癫痫复发预测模型的研究进展,评估了不同模型的贡献与局限性。最后,强调了停药后管理的重要性,包括随访策略和复发后的治疗调整。本综述旨在为临床医生提供停药决策的参考,并指出未来的研究方向,以优化停药策略,降低复发风险,改善患儿预后。This article explores in depth the current research status of drug withdrawal recurrence in children with epilepsy. This article first summarized the incidence rate of epilepsy in children and the universality and limitations of antiseizure medications (ASMs) treatment. The key analysis focuses on the cessation strategy, including the determination of seizure-free time, the process of drug reduction, and the consideration of single-drug and multi-drug combination therapy. Further discussion was conducted on various risk factors for relapse after discontinuation of medication, such as demographic factors, severity of seizures, epilepsy syndrome, seizure type, etiology, abnormal electroencephalogram (EEG), history of febrile seizures and family history, as well as other related diseases or complications. In addition, the research progress of predictive models for childhood epilepsy recurrence was reviewed, and the contributions and limitations of different models were evaluated. Finally, the importance of post-discontinuation management was emphasized, including follow-up strategies and treatment adjustments after relapse. This
