子痫前期是发生于妊娠期特有的高血压,极大地危害母婴健康。目前病因及发病机制尚未完全阐明。已有的研究表明子痫前期可能与全身炎症反应过度激活、氧化应激、免疫紊乱等有关。肠道菌群的失衡可能在炎症激活、免疫失衡、氧化应激等方面发挥作用从而参与子痫前期的发生发展。短链脂肪酸作为肠道菌群的重要代谢产物,在血压、代谢及免疫功能调节和抑制炎症反应等方面具有积极的作用。有研究表明短链脂肪酸的成分含量构成在子痫前期状态下也发生变化,这为进一步探究子痫前期的发病机制及防治提供了新思路。Pre-eclampsia is a unique form of hypertension that occurs during pregnancy and greatly endangers the health of the mother and child. The etiology and pathogenesis have not yet been fully elucidated. Studies have shown that preeclampsia may be associated with over-activation of systemic inflammatory response, oxidative stress, and immune disorders. Imbalance of intestinal flora may play a role in inflammatory activation, immune imbalance, oxidative stress, etc. and thus participate in the development of preeclampsia. As important metabolites of intestinal flora, short-chain fatty acids have positive effects on blood pressure, metabolism and immune function regulation, and inhibition of inflammatory response. Some studies have shown that the composition of short-chain fatty acids also changes in preeclampsia, which provides new ideas for further investigation of the pathogenesis and prevention of pre-eclampsia.
