1例19岁男生因右眼视力下降3月就诊,患者既往过敏性鼻炎病史,2年前躯干、四肢逐渐出现红斑、丘疹、丘疱疹伴瘙痒,且反复发作,长期口服泼尼松片及乌帕替尼缓释片并外涂克立硼罗软膏治疗。检查见:右眼颞下方旁中央角膜锥形扩张,Munson征阳性,未见Fleischer征、Vogt线纹,右眼角膜变薄,但左眼未见明显异常。诊断为特应性皮炎合并右眼圆锥角膜,于外院行右眼角膜胶原交联术,术后随诊3个月病情稳定。A 19-year-old male patient presented with a history of allergic rhinitis due to decreased vision in his right eye for 3 months. Two years ago, the patient gradually developed erythema, papules, and papules with itching on the trunk and limbs, and had recurrent episodes. The patient was treated with long-term oral prednisone tablets and sustained-release Upatinib tablets, as well as topical application of Cleboride ointment. Examination shows: Conical dilation of the central cornea below the temporal lobe in the right eye, positive Munson sign, no Fleischer sign or Vogt lines, thinning of the cornea in the right eye, but no obvious abnormalities in the left eye. Diagnosed with atopic dermatitis combined with keratoconus in the right eye, underwent corneal cross-linking surgery in an external hospital for the right eye, and the condition remained stable after 3 months of follow-up.