AIM To study the effect of the Capsazepin(CZP),an blocker of the transient receptor potential subfamily vanill...
Da-Lu LIU~1,Wen-Ting WANG~2,Lan-Fang DU~2,Da-Wei ZHENG~2,San-Jue HU~(2,*) 1 Student in the Grade 2005,Cadet Squadron No.6,School of the Stomatology 2 PLA Institute of Neurosciences,School of Basic Medicine,Fourth Military Medical University,Xi'an 710033,China
Objective The precise mechanism of painful diabetic neuropathy（PDN） in unmyelinated fibers（C-fibers） remains u...
Xiu-Chao WANG~1,Wei SUN~1,Bei MIAO~(1,2),Wen-Ting WANG~1,Ceng LUO~1,Yi-Hui LIU~1,Fang KUANG~1,Jun-Ling XING~1, Hui XU~1,Gong JU~1,Xue-Jun SONG~2,San-Jue HU~(1,*) 1 Institute of Neuroscience,the Fourth Military Medical University,Xi'an 710033,China 2 Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,China
目的:研究利鲁唑(riluzole)对受损背根节(DRG)A类神经元的不同模式自发放电的作用,并探讨其可能机制。方法:本实验在大鼠L5椎间孔置入不锈钢柱制备大鼠DRG慢性压迫模型(chronic compression of DRG,CCD)上,利用在体单纤维记录的方法观察DRG局部浸浴利鲁唑(500μmol/L)对受损DRG神经元自发放电的影响。结果:(1)CCD大鼠手术后表现出明显的损伤侧机械刺激缩足阈值降低(P<0.05);(2)利鲁唑对受损DRG神经元自发放电具有明显抑制作用(n=30,P<0.05);(3)利鲁唑对非周期放电频率的抑制率显著大于对周期放电频率的抑制率(P<0.05)。结论:利鲁唑对慢性压迫DRGA类神经元的自发放电有显著抑制作用,对非周期放电的抑制作用明显大于对周期放电的作用,呈现出"非周期敏感"的特点,提示受损DRG神经元非周期自发放电行为处于更加不稳定的动力学状态。
Objective Exploring whether the DRG neurons could be devided into different excitability class.What could happ...
Rao-Gang XIE,Jian-Hong DUAN,Wen-Ting WANG,Yi-Hui LIU,Jun-Ling XING~*,San-Jue HU~* Institute of Neuroscience,Fourth Military Medical University,Xi'an 710032,China
