Cardiovascular diseases(CVDs)persistently rank as a leading cause of premature death and illness worldwide.The Hippo signaling pathway,known for its highly conserved nature and integral role in regulating organ size,tissue homeostasis,and stem cell function,has been identified as a critical factor in the pathogenesis of CVDs.Recent findings underscore the significance of the Yes-associated protein(YAP)and the Transcriptional Coactivator with PDZ-binding motif(TAZ),collectively referred to as YAP/TAZ.These proteins play pivotal roles as downstream components of the Hippo pathway,in the regulation of cardiovascular development and homeostasis.YAP/TAZ can regulate various cellular processes such as cell proliferation,migration,differentiation,and apoptosis through their interactions with transcription factors,particularly those within the transcriptional enhancer associate domain(TEAD)family.The aim of this review is to provide a comprehensive overview of the current understanding of YAP/TAZ signaling in cardiovascular physiology and pathogenesis.We analyze the regulatory mechanisms of YAP/TAZ activation,explore their downstream effectors,and examine their association across numerous cardiovascular disorders,including myocardial hypertrophy,myocardial infarction,pulmonary hypertension,myocardial ischemia-reperfusion injury,atherosclerosis,angiogenesis,restenosis,and cardiac fibrosis.Furthermore,we investigate the potential therapeutic implications of targeting the YAP/TAZ pathway for the treatment of CVDs.Through this comprehensive review,our aim is to elucidate the current understanding of YAP/TAZ signaling in cardiovascular biology and underscore its potential implications for the diagnosis and therapeutic intervention of CVDs.
Background:Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer(CRC).However,as the molecular mechanism associated is still unclear,our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC.Methods:HT29 and SW480 cells were treated with curcumin or/and Doxycycline(DOX),and cell viability,colony forming ability,migration and invasion were confirmed by cell counting kit-8(CCK-8),colony forming,Transwell assays.And Yes-associated protein 1(YAP)and PDZ-binding motif(TAZ)signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR(RT-qPCR),western blot,and immunofluorescence assays.Then nude mice xenograft tumor model was constructed,YAP and Ki67 expressions were tested by immunohistochemistry(IHC)staining.Results:In our study,we proved that curcumin significantly inhibited the CRC cell viability,cell migration,and cell invasion abilities.In addition,curcumin inhibited YAP and Transcriptional coactivator with TAZ or the YAP/TAZ signaling axis in CRC cells.Further,in the nude mice model,curcumin treatment significantly decreased the size and weight of xenotransplant tumors.Conclusion:Therefore,curcumin significantly inhibited CRC development and invasion by regulating the YAP/TAZ signaling axis.
