搜索到191950篇“ SUSTAINED“的相关文章
盐酸羟考酮缓释片与硫酸吗啡缓释片治疗中重度癌症疼痛患者的效果比较
2024年
目的探究盐酸羟考酮缓释片与硫酸吗啡缓释片治疗中重度癌症疼痛患者的临床效果。方法102例中重度癌症疼痛患者为研究对象,随机分为研究组和对照组,每组51例。对照组应用硫酸吗啡缓释片进行镇痛治疗,研究组患者则使用盐酸羟考酮缓释片进行镇痛治疗。对比两组患者的镇痛效果、治疗过程中不良反应发生情况以及镇痛前后生活质量评分。结果研究组患者镇痛总有效率为98.04%(50/51),显著高于对照组患者的82.35%(42/51)(P<0.05)。研究组患者不良反应发生率9.80%(5/51)显著低于对照组患者的45.10%(23/51)(P<0.05)。镇痛前两组患者生活质量评分组间差异无显著性(P>0.05);镇痛后两组患者生活质量评分较镇痛前明显降低,且研究组患者生活质量评分(12.23±5.13)分低于对照组的(16.59±4.81)分(P<0.05)。结论对中重度癌症疼痛患者使用盐酸羟考酮缓释片镇痛价值肯定,相较于硫酸吗啡缓释片镇痛效果更好,安全性更高,有助于提高患者的生活质量。
黄丽梅林小艺黄宝玲
关键词:盐酸羟考酮缓释片硫酸吗啡缓释片癌症疼痛生活质量
口服液体缓控释制剂技术的研究进展被引量:1
2024年
目的针对各类口服液体缓控释技术的释药机理、应用特点及局限性进行综述,为此类制剂的开发提供参考。方法查阅国内外相关文献,对口服液体缓控释技术进行整理归纳。结果目前已有基于离子交换树脂和微囊技术的口服液体缓控释制剂上市,此外,微球、固体脂质纳米粒、原位凝胶等技术也应用于口服液体缓控释制剂领域。结论口服液体缓控释给药系统相比于传统固体缓控释制剂,因其口服可接受性良好,剂量调整灵活,给药依从性优势明显,具有良好的开发应用前景。
李佳宸沙康吴正红
关键词:离子交换树脂微囊缓释混悬剂
Bright compact ultrabroadband source by orthogonal laser-sustained plasma
2024年
Laser-sustained plasma(LSP)source featuring high brightness and broadband spectral coverage is found to be powerful in various fields of scientific and industrial applications.However,the fundamental limit of low conversion efficiency constrains the system compactness and widespread applications of such broadband light sources.In this paper,we propose an innovative orthogonal LSP to break through the conversion efficiency limitation.Driven by the elevated conversion efficiency from absorbed laser power to ultraviolet(UV)emission,a compact broadband source(250–1650 nm)with UV spectral radiance exceeding 210 mW=emm2·sr·nmT is achieved with>100W pump laser.With the plot of a two-dimensional refractive index model,we report an important conceptual advance that the orthogonal design eliminates the influence of the negative lensing effect on laser power density.Experimental results unambiguously demonstrate that we achieve a bright compact UV-VIS-NIR source with negligible thermal loss and the highest conversion efficiency to our knowledge.Significant enhancement of 4 dB contrast-to-noise ratio(CNR)in spectral single-pixel imaging has been demonstrated using the proposed ultrabroadband source.By establishing the quantitative link between pumping optics design and plasma absorption,this work presents a compact broadband source that combines superior conversion efficiency and unprecedented brightness,which is essential to high-speed inspection and spectroscopy applications.
Zhaojiang ShiShichao YangHe HuHaodong LeiZhaohua YangXia Yu
关键词:SOURCEORTHOGONALSUSTAINED
Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier
2024年
Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.
Danping WuJiaying ZouJunyi ChenYan LiNa MaWei Dai
关键词:ORNIDAZOLEMETRONIDAZOLE
Chemical oxygen demand oxidation via sustained-release persulfate balls: a rate-compatibility study of flow velocity, releasing, and oxidation
2024年
Identification of chemical oxygen demand(COD)in municipal solid waste(MSW)landfill leachates is a challenging problem.This paper investigated the feasibility of using sodium persulfate(PS),a strong oxidant,as a permeable reactive barrier(PRB)filling material.Firstly,sustained-release persulfate balls were manufactured to adjust the release rate of persulfate,the oxidation agent.In addition,Fe(II)-loaded activated carbon(Fe-AC)was used to help with an even distribution of Fe(II)in the porous medium(PRB in this case).Then,the oxidation efficiency and kinetic rate of COD removal by the sustained-release balls were subjected to batch tests.A mass ratio of 1:1.4:0.24:0.7 for PS:cement:sand:water was the most efficient for COD removal(95%).The breakthrough curve for a 5 mm sustained-release ball revealed that the retardation factor was 1.27 and that the hydrodynamic dispersion coefficient was 15.6 cm^(2)/d.The corresponding half-life of COD oxidation was 0.43 d,which was comparable with the half-life of PS release from sustained-release balls(0.56 d).The sustained-release persulfate balls were shown to be an economical material with a simple recipe and production method when catalyzed by Fe-AC.Compared with cutting-edge methods,sustained-release balls used in PRBs offer significant advantages in terms of both effectiveness and economy for the preparation of sustained-release and catalytic materials.These results verified the feasibility of using sustained-release persulfate balls as a PRB material for COD removal.
Bate BATEDanting ZHANGJianshe YEMin XIAYixin YANGShuai ZHANG
Cardiac infiltration of diffuse large B-cell lymphoma manifesting as sustained ventricular tachycardia:a case report
2024年
Cardiac tumors are rare.However,cardiac metastases can occur in up to 10%of patients with cancer.Among cardiac neoplasms,metastases are much more common than primary cardiac tumors.[1]Metastatic cardiac neoplasms most frequently metastasize from the respiratory system.
Wei CHENKun HUANGWei-Wei GUOFan ZHOUDe-Ning LIAO
关键词:NEOPLASMSSUSTAINEDCARDIAC
Yeast-Controlled Double-Shelled CacO_(3)/CaF_(2)Hollow Nanospheres with Hierarchically Porous for Sustained pH-Sensitive Drug Release
2024年
Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of biomedicine.However,green and facile synthesis of hierarchically porous nanomaterials with beneficial water dispersibility and biocompatibility is still a great challenge.Herein,a novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled HPCaCO_(3)/CaF_(2) hollow nanospheres under the mediation of yeast cells.The biomolecules derived from the secretion of yeast cells are used as conditioning and stabilizing agents to control the biosynthesis of the HPCaCO_(3)/CaF_(2) materials,which exhibit excellent water dispersibility and favorable biocompatibility.The double-shelled CaCO_(3)/CaF_(2) nanospheres hold hierarchically porous structure and have abundant pore channel and large specific surface area,showing high drug-loading and a prolonged drug sustainable release profile by the pore-by-pore diffusion pattern of the hierarchical pores.Otherwise,the HPCaCO_(3) with pH-sensitivity could controllably release drug doxorubicin hydrochloride(DOX)at the acidic tumor microenvironment.Both in vitro and in vivo results demonstrate that HPCaCO_(3)/CaF_(2) has the sustainable pH-sensitive drug release property,showing an enhanced therapeutic effect.Summarily,this study provides a biomimetic strategy to synthesize the hierarchically porous double-shelled hollow nanomaterials for applying in sustainable drug delivery system.
Xinhe LiuYi ChangGuanglei MaTingting LiuPenghui SongHeng YuXueqing RenYuming GuoXiaoming Ma
GREEN TRANSITION,SUSTAINED GROWTH
2024年
As people are becoming increasingly aware of the importance of environmental protection,the traditional energy-intensive and highly polluting industries are becoming outdated,needing to be upgraded or phased out,while low-carbon and clean industries are begining to mushroom.From new-energy vehicles to clean energy,from environmentally friendly building materials to the circular economy sector,the green industry has become a new economic growth pole.
关键词:BECOMINGCIRCULAR
A Sustained Force for Economic Growth
2024年
A green industry chain has been formed in China,in which the latest technologies can be applied and further developed.IN 2018,due to a job change,I came to China and became the head of the Spanish news agency Agencia EFE’s Beijing office.At the end of 2021,I made a brave move from media to college,and started my new career as a teacher at the School of Journalism and Communication at Renmin University of China,which enabled me to get closer to China and the young Chinese.
JAVIER GARCIA
关键词:CLOSERSPANISHCOLLEGE
帕利哌酮缓释片的制备
2024年
目的制备骨架膜控型帕利哌酮缓释片,针对制剂处方和制备工艺进行筛选,并考察其体外释放特性。方法通过检索原研制剂处方和其他仿制药等相关信息,选择以海藻酸钠(SA)、羟丙甲纤维素(HPMC)和聚氧乙烯(PEO)等缓释材料作为凝胶骨架片芯进行研究,筛选不同种类缓释材料及不同比例用量,以确定片芯处方;筛选包衣材料和用量以确定包衣处方;通过考察包衣老化温度和老化时间等,确定缓释片的制备工艺。结果经过优化,确定片芯以SA和HPMC K100LV CR质量比为1∶1作为亲水凝胶骨架,以无水乳糖作为填充剂,硬脂酸镁作为润滑剂;缓释衣膜以乙基纤维素水分散体Surelease、HPMC SH-E3和枸橼酸三乙酯(TEC)作为包衣材料,包衣体系中主要成分乙基纤维素(EC)、HPMC、TEC质量比为80∶20∶15,确定老化工艺:采用包衣锅设备,于55~60℃条件下老化3 h。结论成功制备骨架膜控型帕利哌酮缓释片,制剂处方和制备工艺合理,且体外溶出曲线介于参比制剂(RLD)和对照制剂溶出曲线之间,通过一致性评价的可能性更高。
张美玲朱佳滨王路苑州凯贺敦伟
关键词:缓释片体外释放

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