搜索到10446篇“ CONTROLLED-RELEASE“的相关文章
左乙拉西坦单向释药控释片的制备与释放度评价
2024年
目的:拟研制一种新型左乙拉西坦(levetiracetam,LEV)单向释药控释片。方法:将处方量LEV与载体材料通过溶剂-熔融法制备固体分散体颗粒,干法制粒压片制备药物层,压制保护层后得双层片芯,保护层顶面粘贴保护膜,浸渍法将片芯包衣后,撕掉保护膜即得底面和侧面包衣的LEV单向释药控释片。以体外累积释放度等为评价指标,考察其处方工艺,并进行体外释药模型拟合。结果:最终处方为药物层:LEV原料药250 mg,十八醇62.5 mg,硬脂酸镁6.25 mg;压片硬度为6 kg;保护层:乳糖用量200 mg;包衣层:包衣液为10%EC M70乙醇溶液;包衣增重百分比为10%。LEV单向释药控释片12 h体外累积释放达90%以上,释药行为符合零级释放模型。结论:自制的LEV单向释药控释片处方工艺简单可行、体外释放缓慢平稳,符合控释制剂理想特征。
席雨梦何函星王晓晖郝俊红何朝星杜青
关键词:控释片体外释放
Biochar-compost-based controlled-release nitrogen fertilizer intended for an active microbial community
2024年
Nitrogen(N) fertilizers in agriculture suffer losses by volatilization of N to the air, surface runoff and leaching into the soil, resulting in low N use efficiency(NUE)( 50%) and raising severe environmental pollutions. Controlledrelease nitrogen fertilizers(CRNFs) can control the release of N nutrients to NUE in crop production. Different methods were used to develop new CRNFs.However, different CRNF technologies are still underdeveloped due to inadequate controlling on N releasing time and/or unsustainable diffusion. The study on the influences of CRNF processing parameters on microbial conditions are lacking when the CRNFs composed of various bio-ingredients such as biochar, composts, and biowaste. The complexity of processing methods, material biodegradability, and other physical properties make current CRNFs of questionable value in agricultural production. This research aims to develop a novel biochar-compost-based controlled-release urea fertilizer(BCRUF) to preserve microbial properties carried by the compost. The BCRUF was synthesized by pelletizing the 50:50(dry, wt/wt) mixture of biochar and compost. BCRUF was loaded with urea and then spray-coated with polylactic acid(PLA). The releasing time of two types of BCRUFs, coated and uncoated with PLA, for 80% of N release in water was up to 6 h at three different temperatures(4, 23, and 40 °C), compared to conventional urea fertilizer and commercial environmentally smart N(ESN) fertilizer. The releasing time of coated BCRUF for 80% N release in soil was up to 192 h(8 days). Fourier-transform infrared spectroscopy(FTIR) analysis revealed that no new functional groups were found in the release solution, indicating no new chemical hazards generated. The differential scanning calorimetry(DSC)tests also verified that its thermal stability could be up to 160 °C. The microbe populations in the BCRUF pellets were reduced after the pelleting and drying processes in BCRUF fabrication, but a few bacteria can endure in the air-drying process. BCRUF pellets soaked in
Robiul Islam RUBELLin WEISalman ALANAZIAbdulkarim ALDEKHAILAnne CMCIDREIRAXufei YANGSanjita WASTISamarthya BHAGIAXianhui ZHAO
关键词:BIOCHARCOMPOST
控释掺混肥对麦玉轮作体系农田温室气体排放和硝态氮残留的影响
2024年
为阐明控释肥对冬小麦-夏玉米轮作体系作物产量、温室气体排放和硝态氮残留的影响,该研究以郑单958(夏玉米)和济麦22(冬小麦)为供试材料,设不施氮对照(CK)、常规施氮(FFP)、优化施氮(OPT)、含30%控释尿素的控释掺混肥(夏玉米)和含50%控释尿素的控释掺混肥(冬小麦)(CRBF1)、含50%控释尿素的控释掺混肥(夏玉米)和含70%控释尿素的控释掺混肥(冬小麦)(CRBF2)共5个处理,对比分析了不同处理的冬小麦、夏玉米及周年产量、温室气体排放和土壤硝态氮残留的差异。结果表明,施氮可显著提高麦玉轮作系统单季和周年作物产量(P<0.05)。与FFP相比,CRBF1和CRBF2处理的夏玉米、冬小麦和周年产量分别提高了1.4%~3.0%、1.9%~3.4%和1.6%~3.1%(P>0.05)。施氮显著增加了麦玉轮作体系的土壤N_(2)O和CO_(2)的周年排放(P<0.05)。CRBF1和CRBF2处理的土壤N_(2)O周年排放总量较FFP处理显著降低了27.7%~34.6%(P<0.05)。施氮显著增加了麦玉轮作体系的周年全球增温潜势(GWP)(P<0.05)。CRBF1和CRBF2处理的周年GWP较FFP处理降低了4.2%和5.7%,其中CRBF2处理差异显著(P<0.05)。施氮降低了麦玉轮作体系的周年温室气体排放强度(GHGI)。CRBF1和CRBF2处理的周年GHGI较FFP处理降低了5.6%~8.6%(P>0.05)。与FFP相比,CRBF1和CRBF2处理的100~200 cm土层硝态氮残留降低30.6%~34.3%(P<0.05),减少了硝态氮淋失风险。综上所述,控释掺混肥在稳定作物产量、减少温室气体排放和土壤硝态氮残留方面具有积极作用,研究结果可为麦玉轮作体系的轻简高效氮肥管理提供数据支持和理论支撑。
曹兵高玮李洪杰王学霞王玉霞周晓琳陈延华陈延华赵萌倪小会邹国元赵萌
关键词:温室气体冬小麦-夏玉米轮作控释掺混肥硝态氮残留
控释掺混肥对麦玉轮作体系作物产量和温室气体排放的影响被引量:1
2024年
为探究控释掺混肥一次性施肥对华北平原麦玉(冬小麦和夏玉米)轮作体系作物产量和温室气体排放的影响,于2020~2022年在德州市现代农业科技园区开展田间试验.冬小麦和夏玉米均设不施氮对照(CK)、农户习惯施氮(FFP)、优化施氮(OPT)、CRU1(包膜尿素与普通尿素在冬小麦和夏玉米上的掺混比例分别为5∶5和3∶7)、CRU2(包膜尿素与普通尿素在冬小麦和夏玉米上的掺混比例分别为7∶3和5∶5)共5个处理.对比分析了不同处理的作物产量、氮肥利用效率、施肥经济效益和温室气体排放的差异.结果表明,施氮可显著提高麦玉轮作系统单季和周年作物产量(P<0.05).与FFP相比,CRU1和CRU2处理的夏玉米、冬小麦和周年产量分别提高了0.4%~5.6%、−5.4%~4.1%和−1.1%~3.9%(P>0.05);氮肥吸收利用率、氮肥农学利用率和氮肥偏生产力分别提高了−8.6%~43.4%、2.05~6.24 kg·kg^(−1)和4.24~10.13 kg·kg^(−1);周年净收益提高了0.2%~6.3%.施氮显著增加了麦玉轮作体系的土壤N_(2)O和CO_(2)的周年排放(P<0.05),但对CH4周年排放没有影响(第1年FFP处理除外).CRU1和CRU2处理的土壤N_(2)O周年排放总量较FFP处理显著降低了23.4%~30.2%(P<0.05).施氮显著增加了麦玉轮作体系的周年全球增温潜势(GWP)(P<0.05),但各施氮处理通过提高作物产量降低了温室气体排放强度.与FFP相比,CRU1和CRU2处理的周年GWP降低了9.6%~11.5%(P<0.05),周年温室气体排放强度(GHGI)降低了11.2%~13.8%(P>0.05).综上所述,一次性减量施用控释掺混肥在减少氮肥和人工投入、提高作物产量、经济效益和降低温室气体排放方面具有积极作用,是促进华北平原粮食作物清洁生产的有效氮肥管理措施.
高玮王学霞谢建治陈延华倪小会倪小会董艳芳王甲辰曹兵
关键词:控释掺混肥氮肥利用效率温室气体排放
How Effective Is Cervical Ripening Using the Controlled-Release Dinoprostone Vaginal Delivery System for Primiparas with Unruptured Membranes?
2024年
Background: Labor induction has a low success rate, especially in primiparas with unruptured membranes. Previous studies focused on pregnant women with unruptured membranes, but none specifically targeted primiparas. Aims: To compare the effectiveness of a controlled-release dinoprostone vaginal delivery system for cervical dilatation (PROPESS) with that of mechanical dilation for labor induction in primiparous women with unruptured membranes. Materials and Methods: We retrospectively analyzed the data of 90 primiparas with unruptured membranes (41 and 49 in the PROPESS and mechanical dilation groups, respectively). The primary outcome was the cesarean section (CS) rate. The secondary outcomes were the prevalence of vaginal delivery within 12 or 24 h after the initial insertion, oxytocin usage rate, chorioamnionitis, additional use of mechanical dilation in the PROPESS group, and neonatal outcomes. Results: The CS rate was significantly lower in the PROPESS group than in the mechanical dilation group (p = 0.02). A total of 13 patients (31.7%) delivered within 24 h with PROPESS alone, indicating a significantly higher rate of delivery within 24 h in the PROPESS group (p = 0.02). Fewer patients required additional oxytocin in the PROPESS group than in the mechanical dilation group (p = 0.001). However, 14 (34%) patients in the PROPESS group required additional mechanical cervical dilation, resulting in a longer time to delivery than mechanical dilation. Conclusions: PROPESS significantly reduced CS rates and increased delivery rates 24 h after the initial insertion in primiparas with unruptured membranes compared to mechanical dilatation. However, failure to respond to PROPESS resulted in an overall longer delivery time than that of the conventional mechanical dilation group;therefore, identifying predictors of response to PROPESS is necessary.
Yoshino KinjyoYukiko ChinenTadatsugu KinjoShuko ChinenKeiko Mekaru
关键词:PROPESS
控释掺混肥对夏玉米氮肥利用效率和气态氮损失的影响
2024年
为阐明控释掺混肥对夏玉米产量、氮肥利用效率和气态氮损失的影响,本研究以郑单958为供试材料,设不施氮对照(CK)、常规施氮(FFP)、优化施氮(OPT)、含30%控释尿素的控释掺混肥(CRBF30)和含50%控释尿素的控释掺混肥(CRBF50)共5个处理,对比分析了不同处理的夏玉米产量、氮肥利用效率和气态氮损失(氨挥发和N2O排放)的差异。结果发现,控释掺混肥(CRBF30和CRBF50处理)较FFP处理夏玉米增产1.4%~2.9%(P>0.05),在减氮和一次性施肥的条件下实现了夏玉米稳产。与FFP处理相比,CRBF30和CRBF50处理的氮肥吸收利用率分别提高了8.4个和11.1个百分点,其中CRBF50处理差异显著(P<0.05);氮肥偏生产力分别提高了8.87 kg·kg^(-1)和9.86 kg·kg^(-1)(P<0.05)。与FFP处理相比,控释掺混肥(CRBF30和CRBF50处理)的氨挥发强度和累积氨挥发损失分别降低71.9%~73.5%(P<0.05)和71.59%~72.66%(P<0.05),N2O排放强度和累积排放量分别显著降低了34.5%~41.4%(P<0.05)和33.7%~37.5%(P<0.05)。综上,施用控释掺混肥可兼顾夏玉米稳产、氮肥高效利用并降低氮素气态损失。
曹兵高玮李洪杰王学霞王玉霞谷佳林谷佳林李子双
关键词:夏玉米控释掺混肥氮肥利用效率氨挥发N2O排放
Integrated assessment of yield,nitrogen use efficiency and ecosystem economic benefits of use of controlled-release and common urea in ratoon rice production
2024年
Controlled-release urea(CRU)is commonly used to improve the crop yield and nitrogen use efficiency(NUE).However,few studies have investigated the effects of CRU in the ratoon rice system.Ratoon rice is the practice of obtaining a second harvest from tillers originating from the stubble of the previously harvested main crop.In this study,a 2-year field experiment using a randomized complete block design was conducted to determine the effects of CRU on the yield,NUE,and economic benefits of ratoon rice,including the main crop,to provide a theoretical basis for fertilization of ratoon rice.The experiment included four treatments:(i)no N fertilizer(CK);(ii)traditional practice with 5 applications of urea applied at different crop growth stages by surface broadcasting(FFP);(iii)one-time basal application of CRU(BF1);and(iv)one-time basal application of CRU combined with common urea(BF2).The BF1 and BF2 treatments significantly increased the main crop yield by 17.47 and 15.99%in 2019,and by 17.91 and 16.44%in 2020,respectively,compared with FFP treatment.The BF2 treatment achieved similar yield of the ratoon crop to the FFP treatment,whereas the BF1 treatment significantly increased the yield of the ratoon crop by 14.81%in 2019 and 12.21%in 2020 compared with the FFP treatment.The BF1 and BF2 treatments significantly improved the 2-year apparent N recovery efficiency,agronomic NUE,and partial factor productivity of applied N by 11.47-16.66,27.31-44.49,and 9.23-15.60%,respectively,compared with FFP treatment.The BF1 and BF2 treatments reduced the chalky rice rate and chalkiness of main and ratoon crops relative to the FFP treatment.Furthermore,emergy analysis showed that the production efficiency of the BF treatments was higher than that of the FFP treatment.The BF treatments reduced labor input due to reduced fertilization times and improved the economic benefits of ratoon rice.Compared with the FFP treatment,the BF1 and BF2 treatments increased the net income by 14.21-16.87 and 23.76-25.96%,respectively.Overall,the on
Zijuan DingRen HuYuxian CaoJintao LiDakang XiaoJun HouXuexia Wang
关键词:YIELD
控释尿素释放周期对水稻产量和氮肥利用的影响
2024年
为研究不同释放周期的控释尿素对水稻产量形成及氮素利用的影响,以南粳9108为材料,在总施氮量为270 kg/hm^(2)的条件下,以不施氮(N0)和施用普通尿素(CK)为对照,探讨普通尿素分别搭配释放周期为60 d、80 d、100 d、120 d的4种控释尿素处理(分别记作T1处理、T2处理、T3处理、T4处理)对水稻产量、茎蘖数、干物质积累量及氮肥利用率的影响。结果表明,与单纯施用普通尿素相比,普通尿素搭配控释尿素处理的水稻产量均有显著提高。普通尿素搭配适宜释放周期的控释尿素处理可以增加水稻植株的茎蘖数、叶面积指数,促进干物质与氮素积累,获得较高结实率。与释放周期为120 d的控释尿素相比,释放周期为100 d的控释尿素的氮素释放量更加匹配水稻不同生长发育时期所需的氮素量,氮肥利用率较高。由此可见,普通尿素搭配适宜释放周期的控释尿素能够提高水稻产量和对氮肥的利用率。
刘梦竹王锐冯源王坤庭糜凯亮邢志鹏张洪程张海鹏
关键词:水稻产量控释尿素氮肥利用率
不同品种缓(控)释肥对水稻产量与效益的影响
2024年
缓(控)释肥作为一种根据作物养分需求缓慢释放的新型肥料,对水稻生产有省工节本增效作用。本次试验设6个处理,分别为“汉枫”缓释掺混肥、“贸昇”缓释掺混肥、“住商”缓释掺混肥、中东“绿聚能”缓释掺混肥、“心连心”控释肥、中东复合肥(CK),采用在相同施氮量18 kg/667 m^(2)条件下,比较5种缓(控)释肥施用对南粳9108的产量及效益影响。结果表明,“住商”缓释掺混肥、“贸昇”缓释掺混肥、“汉枫”缓释掺混肥施用效果较好,南粳9108产量分别达680.73、674.89、663.65 kg/667 m^(2),比CK分别增产17.10%、16.09%、14.16%,比CK分别增收148.17、120.33、92.71元/667 m^(2)。
倪艳云吴静雅王飞
复合纳米载体在微波可控释药方面的研究进展
2024年
在现代癌症治疗中,传统化疗药物缺乏靶向性,常伴随严重的毒副作用,限制了化学疗法的临床应用。近年来,随着纳米技术的发展,基于纳米材料的靶向化疗成为一种新的治疗策略,特别是复合纳米材料在微波刺激下的药物释放性能,展现出了优异的应用前景。本文综述了这一领域的最新进展,重点分析了复合纳米材料如何在微波刺激下实现精准的药物释放,以及这种方法在癌症治疗中的潜力。复合纳米材料因其独特的物理化学性质,如高稳定性和良好的生物相容性,被广泛应用于癌症治疗中。在微波刺激下,这些材料能够实现药物的精准控制释放,从而提高治疗效果并减少对健康组织的损害。然而,复合纳米载体在生物体内的分布、靶向性和生物安全性等方面仍面临一定的挑战。例如,纳米粒子的体内稳定性和靶向能力需要进一步优化,以提高其治疗效果和减少副作用。在微波刺激诱导的药物控制释放方面,虽然已取得了一定的成果,但精确控制微波能量的传递和局部组织的加热效果仍是主要挑战之一。此外,如何确保微波能量集中于肿瘤组织而不损害周围健康组织,也是当前研究需要解决的问题。未来,随着纳米技术的不断进步和微波控制技术的改进,预计将开发出更为高效和安全的复合纳米载体,不仅能够提高药物的靶向性和治疗效果,还能在微波刺激下实现更为精准的药物释放控制。综上所述,复合纳米材料在微波刺激下的药物释放性能将是癌症治疗领域的一个重要研究方向,有望为癌症患者带来更有效的治疗选择。
刘雪茹刘叶刘叶惠壮崔斌
关键词:复合纳米材料靶向给药

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