搜索到62篇“ 物质禁断综合征“的相关文章
温针灸对肾阳虚海洛因戒者稽延性戒症状的影响被引量:4
2021年
目的观察温针灸治疗肾阳虚型海洛因戒者稽延性戒症状的临床疗效。方法将56例患者随机分为温针组和自然戒组,每组28例。温针组在美沙酮脱毒治疗结束后行温针治疗;自然戒组在美沙酮脱毒治疗结束后自然戒。观察两组治疗前(T0)、治疗1周后(T1)、治疗2周后(T2)及治疗后(T3)稽延性戒症状评分及躯体症状因子、情绪症状因子、睡眠障碍因子的评分。结果 T1时,温针组症状评分、躯体症状因子、情绪症状因子、睡眠障碍因子评分均较治疗前降低(P<0.05);自然戒组各评分与治疗前比较,差异无统计学意义(P>0.05)。T2、T3时,两组症状评分、躯体症状因子、情绪症状因子评分均较治疗前降低(P<0.05);温针组睡眠障碍因子评分较治疗前降低(P<0.05);自然戒组睡眠障碍因子评分与治疗前比较,差异无统计学意义(P>0.05)。T2时,温针组症状评分、躯体症状因子、睡眠障碍因子评分均低于自然戒组(P<0.05);T3时,温针组症状评分、躯体症状因子、情绪症状因子、睡眠障碍因子评分均低于自然戒组(P<0.05)。结论温针灸能有效改善肾阳虚型海洛因戒者稽延性戒症状,且起效时间早,在改善睡眠障碍方面效果显著。
高晓悦梁艳霍莉莉俞捷顾尤徐姹玥
关键词:温针疗法物质禁断综合征海洛因依赖肾阳虚
Effect of acupuncture in intervening heroin-induced brain damage via regulating ubiquitin-proteasome pathway被引量:2
2018年
Objective:To observe the effect of acupuncture in regulating ubiquitin-proteasome pathway (UPP),and discuss the action of acupuncture in intervening heroin-induced brain damage.Methods:Thirty male Sprague-Dawley (SD) rats were divided into a control group,a model group and an acupuncture group by using the random number table.Rats in the model and acupuncture groups received intramuscular heroin injection for successive 8 d at a progressively increased dose.Afterwards,the injection was suspended for 5 d for withdrawal.The heroin relapse rat model was established by repeating the drug addiction and withdrawal process for 3 times.The control group followed the step of the model establishment,but was given intramuscular injection of normal saline at the stage of addiction and no intervention at the stage of withdrawal;the model group was given intramuscular heroin injection at a progressively increased dose at the addiction stage and no intervention at the withdrawal stage;the acupuncture group was dealt in the same way as the model group at the addiction stage,but received acupuncture at Baihui (GV 20) and Dazhui (GV 14) at the withdrawal stage,with the needles retained for 30 min each time,1 session a day,for successive 5 d.On the 39th day,brain tissues were extracted from the hippocampus and ventral tegmental area (VTA) of the three groups of rats.The apoptosis of brain nerve cells was detected by using terminal deoxynucleotidyl transferase-mediated nick and labeling (TUNEL).The mRNA and protein expressions of ubiquitin (Ub),ubiquitin protein ligase (E3) and 26S were examined by immunohistochemistry and quantitative real-time polymerase chain reaction (RT-qPCR).Results:Compared with the model group,rat's hippocampus and VTA in the acupuncture group showed significantly fewer cells positively stained by TUNEL staining (P〈0.01),and its mRNA and protein expressions of Ub,E3,26S were significantly lower (P〈0.01).Conclusion:Reducing nerve cell apoptosis and reg
Zhang Li-daCao Jiang-pengCai Xing-huiWU Sheng-bingHou Xiao-rongGao Yong-longZhang Rong-junSong Xiao-ge
关键词:PROTEASOMERATS
内关和足三里穴位埋线对海洛因戒后焦虑和睡眠障碍的影响被引量:12
2017年
目的观察内关、足三里穴位埋线对海洛因戒后焦虑和睡眠障碍的影响。方法将67例海洛因成瘾者随机分为内关组(25例)、足三里组(22例)、联合组(内关加足三里组,20例),20 d治疗1次,共治疗4次。采用焦虑自评量表(SAS)和匹兹堡睡眠质量量表(PSQI),观察3组治疗前后焦虑和睡眠情况。结果埋线60 d后,3组SAS总分和标准分、入睡时间和PSQI总分较治疗前显著减少(P<0.05),睡眠时间显著延长(P<0.05);其中,在改善焦虑比较中,联合组>内关组>足三里组(P<0.05);在改善睡眠比较中,联合组疗效优于足三里组、内关组(P<0.05);足三里组、内关组疗效比较差异无统计学意义(P>0.05)。结论内关、足三里、内关加足三里穴位埋线对海洛因戒后焦虑和睡眠障碍均有疗效,其中穴位组合疗效优于单穴,说明穴位组合产生协同治疗效应。
王娜牛相来袁红丽刘欢周钰
关键词:物质禁断综合征海洛因依赖PSQI
Effect of reward alteration following acupuncture for morphine withdrawal rats on neuronal discharges in the ventral medial prefrontal cortex被引量:2
2017年
Objective:To observe the effect of reward alteration following acupuncture for morphine withdrawal rats on the behavior and neuronal discharges in the medial prefrontal cortex (mPFC). Methods:The Sprague-Dawley (SD) rats were randomly allocated into a model group, a confinement group, an electroacupuncture (EA) group, and a control group. Rats with morphine addiction were made by intraperitoneal injection of naloxone (same dose injection of saline for rats in the control group), followed by a 2-week morphine withdrawal. Acupuncture and confinement were completed during the morphine withdrawal period. Upon withdrawal, the rats received conditioned place preference (CPP) training and open field test. The multi-channel neural signal processor was used in the electrophysiological experiment to measure the neuronal discharges in different subareas of prefrontal cortex in CPP box and aversion box. Results:Rats in the model group and the confinement group spent longer period of time in CPP box than those in the EA group and the control group (allP〈0.01); there was no statistically significant difference between the EA group and the control group. The total distances of movement by rats in the model group and the confinement group were longer than those in the EA group and the control group (allP〈0.01). The mPFC neuronal discharge frequencies were compared between morphine preference box and aversion box. The mPFC neuronal discharge frequencies in the model group and the confinement group were higher than those in the EA group and the control group (allP〈0.05); there was no statistically significant difference between the EA group and the control group. Conclusion:Acupuncture can effectively interfere with the reward alteration following morphine withdrawal, possibly because of its involvement with the mPFC neuronal discharges.
张博渊张龙早刘胜韩丑萍(译)
关键词:REWARDRATS
Acupuncture with Methadone for heroin withdrawal syndrome: a meta-analysis of randomized controlled trials被引量:3
2016年
Objective: To assess the efficacy of acupuncture plus Methadone in treating heroin withdrawal syndrome. Methods: According to the requirements of evidence-based medicine, the inclusion criteria, exclusion criteria and retrieval strategy were set for original documents. Randomized controlled trials(RCTs) involving acupuncture plus Methadone in treating heroin withdrawal syndrome were retrieved from China National Knowledge Infrastructure Database(CNKI),Wanfang Academic Journal Full-text Database(Wanfang), Chinese Biomedical Literature Database(CBM), Chongqing VIP Database(CQVIP), PubM ed, Cochrane Library and EMBASE. According to the Cochrane Handbook for Systematic Reviews of Interventions, each included trial was assessed strictly including risk of bias and quality evaluation. Meta-analysis and descriptive-analysis were conducted using the RevM an 5.3 software. Results: A total of 8 trials involving 931 patients were included. Meta-analysis showed that there was no statistical significance [RR=1.05; 95%CI(0.99, 1.11); P=0.11] in comparing total effective rate between the acupuncture plus Methadone and Methadone alone; the cure rate of acupuncture plus Methadone was higher than that of Methadone alone[RR=1.45; 95%CI(1.19, 1.78); P=0.0003]; the relapse rate of the acupuncture plus Methadone was lower [RR=0.691;95%CI(0.60, 0.80); P〈0.00001]. On the basis of these results, the method recommended by the Grading of Recommendations Assessment, Development and Evaluation(GRADE) was taken to evaluate the quality of the evidence. It showed that the level of the evidence was low and it was weakly recommended. Conclusion: According to the included trials, acupuncture plus Methadone in treating heroin withdrawal syndrome is more effective and better than Methadone alone, but it still needs more high-quality, large sample, and polycentric researches to confirm it.
张阳徐伟宋小鸽张月陈玲冯静(译)
关键词:META-ANALYSIS
针刺“鬼穴”对甲基苯丙胺依赖者焦虑抑郁情绪疗效观察被引量:10
2015年
目的观察针刺"鬼穴"对甲基苯丙胺(MA)依赖者焦虑抑郁情绪的干预效果。方法将60例男性MA依赖者随机分为对照组、针刺Ⅰ组和针刺Ⅱ组。对照组不予任何干预措施,针刺Ⅰ组取双侧内关、神门、足三里、三阴交、华佗夹脊穴(T5、L2),针刺Ⅱ组取水沟、上星、承浆及双侧大陵、间使、申脉、曲池。针刺组均每星期治疗3次,共12次。分别于治疗前,治疗1、2、3、4星期后观察各组汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)的评分情况。结果治疗1星期后,针刺Ⅱ组HAMA、HAMD评分显著低于对照组(P<0.05),治疗2、3、4星期后,针刺Ⅰ组和针刺Ⅱ组HAMA、HAMD评分均显著低于对照组(P<0.05),治疗2、3星期后,针刺Ⅱ组HAMD评分显著低于针刺Ⅰ组(P<0.05)。但治疗4星期后,针刺Ⅰ组与针刺Ⅱ组HAMD评分比较差异无统计学意义(P>0.05)。结论针刺"鬼穴"和针刺前期研究筛选出的有效体穴均可改善MA依赖者的焦虑抑郁情绪,但可能针刺"鬼穴"在治疗中期能更好地改善MA依赖者的抑郁症状。
陶颖曾亮梁艳宗蕾
关键词:针刺物质禁断综合征焦虑抑郁
电针对甲基苯丙胺成瘾者戒症状的临床观察被引量:11
2014年
目的观察电针对甲基苯丙胺成瘾者戒症状的治疗效果,为甲基苯丙胺依赖的治疗提供客观临床依据。方法将60例男性甲基苯丙胺成瘾者随机分为对照组和电针组,采用《甲基苯丙胺戒症状评分量表》、《汉密尔顿焦虑量表》和《汉密尔顿抑郁量表》观察患者治疗前及治疗1~4星期后各量表积分及戒症状的变化。结果电针组相对于对照组在改善甲基苯丙胺依赖者戒症状、焦虑症状和抑郁症状方面疗效明显(P〈0.05),在治疗后4星期以上症状改善最为显著(P〈0.01)。结论电针对于甲基苯丙胺戒症状、情绪焦虑和抑郁症状具有治疗作用,可以作为有效的治疗方法应用于临床以治疗甲基苯丙胺戒症状。并且以上症状的改善与针刺刺激量呈正相关。
梁艳张雪纯徐波宗蕾
关键词:物质禁断综合征电针
针刺干预甲基苯丙胺戒者记忆障碍的ERP观察被引量:8
2013年
目的研究针刺干预甲基苯丙胺戒者记忆障碍的中枢机制。方法以改善认知障碍为主要治疗策略,利用NuAmps 40导事件相关电位系统,从不同记忆负荷水平记录并比较甲基苯丙胺戒者对3类汉字(包括毒品主要相关词、毒品次要相关词、无关词)的反应,分析甲基苯丙胺戒者针刺治疗前后的工作记忆状态与ERP改变的对应关系。结果甲基苯丙胺戒者针刺治疗后1-back的P3波幅显著高于2-back,P<0.05,1-back条件下甲基苯丙胺戒者针刺治疗前后P3峰值有显著组间差异,P<0.05。2-back条件下针刺治疗前后无显著性差异。简单分析表明顶区(PZ电极)P3峰值有显著组间差异;1-back条件下甲基苯丙胺戒者针刺治疗前后P3峰值有显著组间差异,P<0.05;2-back条件下甲基苯丙胺戒者治疗前后P3峰值无显著组间差异,差异波的N450成分主要分布于顶区位置,且分布在脑区范围较大。结论 PZ电极是毒品相关n-back任务中P3成分较为明显的电极,针刺可能通过作用于此记忆位点对甲基苯丙胺所致记忆障碍产生治疗作用。
李明哲徐平李煜虎力
关键词:针刺物质禁断综合征记忆障碍事件相关电位
针刺不同穴位对海洛因戒后焦虑和抑郁情绪的影响被引量:9
2013年
目的探讨针刺不同穴位组对海洛因成瘾者戒后焦虑和抑郁情绪的影响。方法将90例男性海洛因成瘾者随机分为针刺Ⅰ组(T5夹脊穴)30例、针刺Ⅱ组(内关穴)30例和针刺Ⅲ组(T5夹脊穴+内关穴)30例,针刺治疗4星期,每星期3次,共12次。采用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)和汉密尔顿抑郁量表(Hamilton depression scale,HAMD)观察患者治疗前及治疗1~4星期后症状的变化。结果治疗后各组在改善海洛因依赖者戒后焦虑症状和抑郁症状方面疗效明显(P<0.05);在治疗2星期后,针刺Ⅲ组优于针刺Ⅱ组(P<0.05);在治疗3星期后,针刺Ⅰ组在改善焦虑症状方面优于针刺Ⅱ组(P<0.05);在治疗4星期后,针刺Ⅲ组在改善抑郁症状方面优于针刺Ⅰ组(P<0.05)。结论针刺对于海洛因成瘾者戒后焦虑和抑郁情绪具有治疗作用;针刺T5夹脊穴在治疗海洛因成瘾者戒后焦虑症状方面较针刺内关穴具有优势;T5夹脊穴+内关穴在改善海洛因成瘾者戒后焦虑和抑郁情绪方面具有协同效应。
许静侯文光梁艳徐波宗蕾
关键词:物质禁断综合征针刺
针灸治疗阿片依赖戒后稽延期戒症状的临床研究进展被引量:3
2013年
对近10年来针灸治疗阿片类依赖稽延期戒症状的临床研究文献进行整理,对耳针及耳穴贴压、体针、电针、头针及综合疗法等不同针灸治疗方法进行分类总结。
徐波宗蕾侯文光
关键词:耳穴贴压物质禁断综合征

相关作者

宗蕾
作品数:72被引量:731H指数:17
供职机构:上海中医药大学附属岳阳中西医结合医院
研究主题:针刺 电针 海洛因依赖 针灸 物质禁断综合征
梁艳
作品数:59被引量:223H指数:11
供职机构:上海中医药大学附属岳阳中西医结合医院
研究主题:电针 针刺 物质禁断综合征 海洛因依赖 苯丙胺
徐波
作品数:12被引量:65H指数:5
供职机构:上海中医药大学
研究主题:成瘾者 苯丙胺 戒断症状 物质禁断综合征 对甲基
许静
作品数:6被引量:45H指数:4
供职机构:上海中医药大学附属岳阳中西医结合医院
研究主题:物质禁断综合征 海洛因依赖者稽延性戒断症状 海洛因依赖 夹脊 阿片类药物成瘾
侯文光
作品数:111被引量:630H指数:15
供职机构:上海中医药大学附属岳阳中西医结合医院
研究主题:电针 针刺 不稳定膀胱 特异性研究 针刺治疗