The structure of a room temperature asymmetrical dicationic ionic liquid (ADIL), 1-(pyridinium-l-yl) propane- (1-methylpiperidinium) bi[bis(tfifluoromethanesulfonyl)imide] ([PyC3Pi][NTf2]2), was studied by the X-ray difo fraction method. Meanwhile, thermal analysis of [PyC3Pi][NTf2]2 was also studied using non-isothermal thermo- gravimetric analysis (TGA). The title crystal belongs to the triclinic with space group Pi and unit-cell parameters a : 0.95217 (8) nm, b = 1.05129 (11 ) nm, c = 1.70523 (14) nm, ct = 89,759 (8)°,β = 80.657 (7)°, γ=68.007 (9)°, and F(000) = 792. Thermal stability and thermal decomposition kinetics of the title compound were also investigated using TGA under the atmosphere of highly pure nitrogen. Heating curves at different rates were cor- related with kinetic equations Friedman and ASTM (also called iso-conversion method). The values of average activation E (kJ·mol^-1 ) and pre-exponential constant lgA are 149.58 kJ. mol- 1 and 8.83, respectively, which were obtained by the two methods. The kinetic model function, activation energy and pre-exponential constant of this reaction using the multivariate non-linear-regression method were f(a) = (1 -a)(1 + 4.1870a), 151.04 kJ·mol^-1 and 8.81, respectively, which were basically consistent with iso-conversion methods.
Jun WangManman WangXuzhao YangWenyuan ZouXiang Chen
The present study was designed to investigate the anticonvulsant effect of series phthalimides possessing an N-aromatic amines moiety substituted at position 2 (2-7). The compounds synthesized using phthalic anhydride and various amines in reflux synthesizer. The chemical structures of the titled compound were confirmed by physical and spectra analysis. All the synthesized compounds were evaluated in vivo for antiepileptic activity by using standard experimental models. Compounds: 2-(3H-1, 2, 4-Triazole-3-y) isoindoline-1, 3-dione (2), Ethyl-4(1, 3-dioxoisoindoline-2-yl) benzoate 3 and 2-(4-nitrophenyl) isoindoline-1,3dione (7) were found significantly (P 〈 0.01-0.00001) delayed the onset and antagonized picrotoxin-induced seizures.
Omran N. R. FhidShaban E. A. SaadTalal H. ZeglamAsma EswayahTariq ElmougEsra AlnnasYousra HaroonAhmed A. EldepAbdelhamed Ebzabez