目的:运用Meta方法评价玻璃体切除(PPV)联合内界膜剥除术(ILMP)治疗糖尿病性黄斑水肿(DME)临床疗效。方法:检索自从建库以来至2022年12月的维普中文期刊数据库(VIP)、中国生物医学文献数据库(CBM)、万方数据库(Wanfang Data)、中国知网(CNKI)、PubMed、Embase、Cochrane、等相关文献,搜集PPV联合ILMP治疗DME的临床随机对照试验(RCT)的相关文献研究,使用RevMan5.4、Stata17.0等软件对纳入文献的相关数据进行统计学分析。结果:本研究纳入7项文献,合计431只眼。Meta分析结果表明,1) 最佳矫正视力(BCVA):术后1个月(MD = −0.26, 95%CI [−0.37, −0.14], z = 4.30, P MD = −0.13, 95%CI [−0.21, −0.04], z = 2.94, P = 0.003 MD = −0.11, 95%CI [−0.16, −0.06], z = 4.22, P MD = −0.08, 95%CI [−0.13, −0.03], z = 3.36, P = 0.0008 MD = −47.11, 95%CI [−50.69, −43.53], z = 25.77, P MD = −53.62, 95%CI [−100.78, −6.45], z = 2.23, P = 0.03 Objective: To evaluate the clinical efficacy of vitrectomy combined with inner limiting membrane peeling (ILMP) in the treatment of diabetic macular edema (DME). Methods: Relevant articles were searched from VIP, CBM, Wanfang Data, CNKI, PubMed, Embase, Cochrane Library and other databases from the establishment of the database to December 2022. The relevant literatures of randomized controlled trials (RCTS) of PPV combined with ILMP in the treatment of DME were collected. Stata17.0 and RevMan5.4 software were used for Meta-analysis of the inclusion study. Results: A total of 7 RCTS were included in the experiment with a total of 431 eyes. The results of Meta-analysis showed that 1) Best corrected visual acuity (BCVA): The mean changes in BCVA at 1 month (MD = −0.26, 95%CI [−0.37, −0.14], z = 4.30, P MD = −0.13, 95%CI [−0.21, −0.04], z = 2.94, P = 0.003 MD = −0.11, 95%CI [−0.16, −0.06], z = 4.22, P MD = −0.08, 95%CI [−0.13, −0.03], z = 3.36, P = 0.0008 MD = −53.62, 95%CI [−100.78, −6.45], z = 2.23, P = 0.03 MD = −47.1
